What changed for Adam and Eve when they left the Garden?
Their circumstances changed completely: they had to work by the sweat of their brow, and they faced weeds and thistles, sickness, disease, war, famine, and the curse. None of that was present in the Garden, so life became an entirely different set of conditions.
Les teaches that when Adam and Eve came out of the Garden, everything changed and all circumstances changed. They now had to work by the sweat of their face, or brow as he likes to put it. They had weeds and thistles, sickness and disease, war and famine, and the curse fell. In the Garden they had none of that, so it was a whole different set of circumstances.