How much destruction and loss of life has already happened by the fourth trumpet?

Les explains that by the time of the fourth trumpet, the destruction is already horrible. There has been a tremendous loss of life and living things—not only the human race but also living things in the sea and animal life—all coming under the wrath of God. The third trumpet had already turned a third of the waters to wormwood, and many men died because the waters were made bitter. At the fourth trumpet, a third of the sun, moon, and stars are smitten so that the day does not shine for a third part. Then an angel flies through heaven crying, 'Woe, woe, woe, to the inhabitants of the earth' because of the three trumpets yet to sound. Les points out that even though it is already horrible, the angel says it is nothing compared to what is left.