Will lost Gentiles be held responsible at the great white throne for rejecting the opportunity they had?
Yes, lost Gentiles will be held responsible at the great white throne for rejecting their opportunity. They cannot claim they never had a chance, because they had the same opportunity as the covenant people, having rested on Abraham's root and fatness, but they refused it.
Les explains that just as Israel rested on the root and fatness of Abraham, the Gentile world is now in a place of privilege and blessing with an opportunity to hear the Gospel and be saved. However, not every Gentile will be saved. Every Gentile has an opportunity, and every Gentile will be held responsible when they come to the great white throne lost. They cannot say they never had a chance; God will say they did have a chance, having rested on Abraham's root and fatness, and had just as much opportunity as the covenant people did in the past, but they refused it. Les stresses that Christ died for all sins of the world, and every human being has been reconciled and pardoned so far as God is concerned, but it is all for nothing until they appropriate it by faith like Abraham. God does not require someone to know the Bible from cover to cover before being saved.