Which Babylon is Isaiah chapter 13 talking about?

Les teaches that Isaiah 13 is talking about the ancient city of Babylon, the capital of Nebuchadnezzar's empire. He explains that this city would never be inhabited or dwelled in from generation to generation; the Arabian would not pitch his tent there, nor would shepherds make their fold there. Instead, wild beasts of the desert would lie there, houses would be full of doleful creatures, owls would dwell there, satyrs would dance, and wild beasts of the island would cry in their desolate houses. Les says God put such a curse upon that ancient city that it would never be rebuilt, so it will not become a center of commerce and politics and religion again. He notes that regardless of what man may try to do, many things said in Scripture cannot be done.