Did Isaac struggle or fight back when Abraham laid him on the altar?
No. Scripture gives no indication that Isaac struggled or fought back when Abraham laid him on the altar. Instead, in complete obedience, he allowed Abraham to lay him upon that altar. This foreshadows Christ's own obedience unto death, as the Old Testament previewed what took place in the New.
Les explains that the question is asked whether Scripture indicates Isaac struggled, fought back, or tried to lay old Abraham low. The answer is no; in complete obedience Isaac let Abraham lay him upon that altar. Les connects this to the New Testament, noting that Old Testament events like this were a preview of what took place in the New, just as the Lord Jesus Himself was obedient unto that kind of death. The broader passage shows that God did not spare His Son but gave Him up, and believers can rest because if God is for us, who can be against us?
And they came to the place which God had told him of; and Abraham built an altar there, and laid the wood in order, and bound Isaac his son, and laid him on the altar upon the wood.